Abstract
We propose an ultrasensitive SERS-based peptide biosensor platform to monitor phosphorylation catalyzed by kinase in a dynamic format. The developed SERS strategy has a short response time with potential to monitor phosphorylation in live cells.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Biosensing Techniques / methods*
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Cell Line, Tumor
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DNA, Single-Stranded / chemistry
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Gold / chemistry
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Humans
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Metal Nanoparticles / chemistry
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Oligodeoxyribonucleotides / chemistry
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Phosphorylation
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Proto-Oncogene Proteins c-abl / chemistry*
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Pyridines / chemistry
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Spectrum Analysis, Raman
Substances
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DNA, Single-Stranded
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Oligodeoxyribonucleotides
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Pyridines
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4-thiopyridine
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Gold
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Proto-Oncogene Proteins c-abl