Conditions for Waveblock Due to Anisotropy in a Model of Human Ventricular Tissue

Nina N Kudryashova; Ivan V Kazbanov; Alexander V Panfilov; Konstantin I Agladze

doi:10.1371/journal.pone.0141832

Conditions for Waveblock Due to Anisotropy in a Model of Human Ventricular Tissue

PLoS One. 2015 Nov 2;10(11):e0141832. doi: 10.1371/journal.pone.0141832. eCollection 2015.

Authors

Nina N Kudryashova¹, Ivan V Kazbanov², Alexander V Panfilov¹, Konstantin I Agladze³

Affiliations

¹ Life Science Center, Moscow Institute of Physics and Technology, Dolgoprudny, Russia; Department of Physics and Astronomy, Ghent University, Ghent, Belgium.
² Department of Physics and Astronomy, Ghent University, Ghent, Belgium.
³ Life Science Center, Moscow Institute of Physics and Technology, Dolgoprudny, Russia.

Abstract

Waveblock formation is the main cause of reentry. We have performed a comprehensive numerical modeling study of block formation due to anisotropy in Ten Tusscher and Panfilov (2006) ionic model for human ventricular tissue. We have examined the border between different areas of myocardial fiber alignment and have shown that blockage can occur for a wave traveling from a transverse fiber area to a longitudinal one. Such blockage occurs for reasonable values of the anisotropy ratio (AR): from 2.4 to 6.2 with respect to propagation velocities. This critical AR decreases by the suppression of INa and ICa, slightly decreases by the suppression of IKr and IKs, and substantially increases by the suppression of IK1. Hyperkalemia affects the block formation in a complex, biphasic way. We provide examples of reentry formation due to the studied effects and have concluded that the suppression of IK1 should be the most effective way to prevent waveblock at the areas of abrupt change in anisotropy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Action Potentials
Anisotropy
Humans
Hyperkalemia / physiopathology
Models, Cardiovascular*
Potassium Channels / metabolism
Ventricular Function*

Substances

Potassium Channels

Grants and funding

The research was fully supported by two sources: the Ministry of Education and Science of the Russian Federation (Federal Program “5top100”) and FWO-Flanders. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.