Cyclopentadiene-Phosphine/Palladium-Catalyzed Synthesis of Indolizines from Pyrrole and 1,4-Dibromo-1,3-butadienes

Wei Hao; Han Wang; Qingyu Ye; Wen-Xiong Zhang; Zhenfeng Xi

doi:10.1021/acs.orglett.5b02959

Cyclopentadiene-Phosphine/Palladium-Catalyzed Synthesis of Indolizines from Pyrrole and 1,4-Dibromo-1,3-butadienes

Org Lett. 2015 Nov 20;17(22):5674-7. doi: 10.1021/acs.orglett.5b02959. Epub 2015 Nov 2.

Authors

Wei Hao¹, Han Wang¹, Qingyu Ye¹, Wen-Xiong Zhang¹, Zhenfeng Xi¹

Affiliation

¹ Beijing National Laboratory for Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University , Beijing 100871, China.

PMID: 26522791
DOI: 10.1021/acs.orglett.5b02959

Abstract

The cyclopentadiene-phosphine ligand (L1) and palladium were found to be an efficient catalyst system to activate the α-C(sp(2))-H bond of pyrrole and indole derivatives. Various alkenyl or aryl dibromides could be used to react with pyrrole and indole derivatives to afford multisubstituted indolizines in high yields.

Publication types

Research Support, Non-U.S. Gov't