Status of and prospects for cancer vaccines against hepatocellular carcinoma in clinical trials

Biosci Trends. 2016 May 23;10(2):85-91. doi: 10.5582/bst.2015.01128. Epub 2015 Nov 2.

Abstract

Current therapies to treat advanced hepatocellular carcinoma (HCC) are not satisfactory because of the high rate of recurrence after treatment and because of severe complications after surgery. Cancer vaccines have been studied for decades to achieve effective, micro-invasive, long-lasting anti-tumor action. Cancer vaccines are designed to promote tumor-specific immune responses and increase specific cytotoxic CD8-positive T cells. This review summarizes 16 phase I clinical trials of cancer vaccines against HCC that have been conducted over the past 10 years. According to those trials, the Alpha fetoprotein (AFP), Glypican-3 (GPC3), and Multidrug resistance-associated protein 3 (MRP3) vaccines were well tolerated and safe. Some early clinical trials have shown that vaccination resulted in a large number of T cells activated by a specific tumor-associated antigen in the circulation, but clinical outcomes were not satisfactory. This may be because targets for immunosuppressive agents have yet to be clearly determined in HCC. Therapeutic regimens that combine activative agents and suppressive agents may profoundly improve clinical outcomes for patients with HCC in the future.

MeSH terms

  • Cancer Vaccines / adverse effects
  • Cancer Vaccines / therapeutic use*
  • Carcinoma, Hepatocellular / immunology
  • Carcinoma, Hepatocellular / prevention & control*
  • Clinical Trials as Topic
  • Humans
  • Liver Neoplasms / immunology
  • Liver Neoplasms / prevention & control*
  • Models, Immunological
  • Neoplasm Proteins / immunology
  • Recurrence
  • Vaccination / adverse effects
  • Vaccination / methods

Substances

  • Cancer Vaccines
  • Neoplasm Proteins