Sunitinib loaded chitosan nanoparticles formulation and its evaluation

Int J Biol Macromol. 2016 Jan:82:952-8. doi: 10.1016/j.ijbiomac.2015.10.079. Epub 2015 Oct 29.

Abstract

The nano-polymeric pharmaceutical excipient such as chitosan nanoparticles (CS-NPs) were synthesized for formulating the anticancer drug Sunitinib (STB). The formulation was done through the simple ionic cross linking method. The prepared formulation was characterized by DLS, SEM, FT-IR and XRD. The DLS study reveals that the Sunitinib loaded chitosan nanoparticles (SNB-CS-NPs) were in the size range of < 200 nm. Encapsulation of Sunitinib and validation for the formulation was done using UV spectrophotometry. In vitro drug release and its cytotoxic studies were performed for STB-CS-NPs. This study implies the novel drug delivery system for Sunitinib for the effective sustained delivery.

Keywords: Chitosan nanoparticles; Ionic crosslinking; Sunitinib.

MeSH terms

  • Angiogenesis Inhibitors / administration & dosage*
  • Angiogenesis Inhibitors / chemistry*
  • Chemistry, Pharmaceutical
  • Chitosan / chemistry*
  • Drug Carriers / chemistry
  • Drug Delivery Systems
  • Drug Liberation
  • Indoles / administration & dosage*
  • Indoles / chemistry*
  • Kinetics
  • Nanoparticles / chemistry*
  • Nanoparticles / ultrastructure
  • Particle Size
  • Pyrroles / administration & dosage*
  • Pyrroles / chemistry*
  • Spectroscopy, Fourier Transform Infrared
  • Sunitinib
  • X-Ray Diffraction

Substances

  • Angiogenesis Inhibitors
  • Drug Carriers
  • Indoles
  • Pyrroles
  • Chitosan
  • Sunitinib