Abstract
Four phytochemical constituents were isolated from Panax ginseng root by repeated column chromatography (CC), medium pressure liquid chromatography (MPLC), high-speed counter current chromatography (HSCCC), and semi-preparative HPLC. Their structures were elucidated as the dammarane-type triterpene saponins ginsenoside-Rg18 (1), 6-acetyl ginsenoside-Rg3 (2), ginsenoside-Rs11 (3), and ginsenoside-Re7 (4) based on spectral data. Compounds 1-4 from P. ginseng root were new compounds from nature. They showed good hydroxyl radical scavenging activity and anti-bacterial activity against Escherichia coli and Staphylococcus aureus. However, they did not show any anti-inflammatory activity. In addition, they inhibited the growth of adenocarcinoma gastric stomach cells. Among them, ginsenoside-Rs11 (3) showed the best anti-oxidative, anti-bacterial, and anti-cancer activities.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / analysis*
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology
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Antineoplastic Agents, Phytogenic / analysis*
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Antioxidants / analysis*
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Antioxidants / isolation & purification
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Antioxidants / pharmacology
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Chromatography, High Pressure Liquid
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Dammaranes
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Escherichia coli / drug effects
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Escherichia coli Infections / drug therapy
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Ginsenosides / analysis*
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Ginsenosides / isolation & purification
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Ginsenosides / pharmacology
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Humans
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Panax / chemistry*
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Plant Roots / chemistry*
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Staphylococcal Infections / drug therapy
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Staphylococcus aureus / drug effects
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Stomach Neoplasms / drug therapy
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Triterpenes / analysis*
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Triterpenes / isolation & purification
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Triterpenes / pharmacology
Substances
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Anti-Bacterial Agents
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Antineoplastic Agents, Phytogenic
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Antioxidants
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Ginsenosides
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Triterpenes