Associations of non-invasive measures of arterial structure and function, and traditional indicators of cardiovascular risk in adults with cerebral palsy

Patrick G McPhee; Jan Willem Gorter; Lisa M Cotie; Brian W Timmons; Todd Bentley; Maureen J MacDonald

doi:10.1016/j.atherosclerosis.2015.09.035

Associations of non-invasive measures of arterial structure and function, and traditional indicators of cardiovascular risk in adults with cerebral palsy

Atherosclerosis. 2015 Dec;243(2):462-5. doi: 10.1016/j.atherosclerosis.2015.09.035. Epub 2015 Oct 9.

Authors

Patrick G McPhee¹, Jan Willem Gorter², Lisa M Cotie³, Brian W Timmons⁴, Todd Bentley⁵, Maureen J MacDonald⁶

Affiliations

¹ Department of Kinesiology, McMaster University, 1280 Main St. W., Hamilton, ON, L8S 4K1, Canada. Electronic address: mcpheepg@mcmaster.ca.
² CanChild Centre for Childhood Disability Research, Department of Pediatrics, McMaster University, 1400 Main St. W., Hamilton, ON, L8S 1C7, Canada. Electronic address: gorter@mcmaster.ca.
³ Department of Kinesiology, McMaster University, 1280 Main St. W., Hamilton, ON, L8S 4K1, Canada. Electronic address: cotielm@mcmaster.ca.
⁴ Department of Kinesiology, McMaster University, 1280 Main St. W., Hamilton, ON, L8S 4K1, Canada; Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster University, 1400 Main St. W., Hamilton, ON, L8S 1C7, Canada. Electronic address: timmonbw@mcmaster.ca.
⁵ Department of Medicine, Division of Physical Medicine and Rehabilitation, McMaster University, 1280 Main St. W., Hamilton, ON, L8S 4K1, Canada. Electronic address: msksportdoc@hotmail.com.
⁶ Department of Kinesiology, McMaster University, 1280 Main St. W., Hamilton, ON, L8S 4K1, Canada. Electronic address: macdonmj@mcmaster.ca.

PMID: 26520900
DOI: 10.1016/j.atherosclerosis.2015.09.035

Abstract

Background: Persons with cerebral palsy (CP) have mobility limitations and may be at increased risk for cardiovascular disease (CVD).

Aims: To determine the feasibility of assessing novel CVD risk indicators and to identify predictors of CVD risk in a clinic-based group of adults with CP.

Methods: In an observational study, we examined 42 adults with CP (mean age 33.5 ± 12.3 yr). Traditional (resting blood pressure, smoking status and lipids) and novel CVD risk indicators (endothelial function, arterial stiffness, and carotid wall thickness) were assessed.

Results: Measures of endothelial function and central arterial stiffness were conducted in 100% and 83% of participants, respectively. Age was the strongest independent predictor of vascular health (cIMT, Age, R square = 0.576, p = 0.001).

Conclusion: Non-invasive measures of arterial structure and function are feasible to assess and may assist in the prediction of CVD risk in adults with CP.

Keywords: Adult; Arterial stiffness; Cardiovascular health; Carotid intima media thickness; Cerebral palsy; Endothelial function.

Publication types

Observational Study
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Age Factors
Biomarkers / blood
Blood Pressure
Cardiovascular Diseases / blood
Cardiovascular Diseases / diagnosis*
Cardiovascular Diseases / etiology
Cardiovascular Diseases / physiopathology
Carotid Intima-Media Thickness
Cerebral Palsy / complications*
Cerebral Palsy / diagnosis
Cerebral Palsy / physiopathology
Cross-Sectional Studies
Diagnostic Techniques, Cardiovascular*
Endothelium, Vascular / metabolism
Endothelium, Vascular / physiopathology
Feasibility Studies
Female
Health Status
Humans
Lipids / blood
Male
Middle Aged
Mobility Limitation*
Ontario
Predictive Value of Tests
Prognosis
Risk Factors
Smoking / adverse effects
Vascular Stiffness
Young Adult

Substances

Biomarkers
Lipids