Quantitative Indexes of Leukocytes in Spontaneously Hypertensive Rats During Various Periods of Arterial Hypertension Development

O I Aliev; A M Anishchenko; A V Sidekhmenova; A Yu Shamanaev; E P Fedorova; M B Plotnikov

doi:10.1007/s10517-015-3056-9

Quantitative Indexes of Leukocytes in Spontaneously Hypertensive Rats During Various Periods of Arterial Hypertension Development

Bull Exp Biol Med. 2015 Oct;159(6):715-7. doi: 10.1007/s10517-015-3056-9. Epub 2015 Oct 31.

Authors

O I Aliev¹, A M Anishchenko², A V Sidekhmenova², A Yu Shamanaev², E P Fedorova², M B Plotnikov²

Affiliations

¹ Laboratory for Pharmacology of Blood Circulation, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia. nbp2001@mail.ru.
² Laboratory for Pharmacology of Blood Circulation, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.

PMID: 26519274
DOI: 10.1007/s10517-015-3056-9

Abstract

SHR rats were examined in the period before arterial hypertension development (5th week), during the increase in BP (6th-10th weeks), and under conditions of constantly elevated BP (11th-12th weeks). The total number of leukocytes did not differ in SHR and normotensive WKY rats. However, the relative number of lymphocytes and monocytes was shown to differ in various periods of arterial hypertension development. Our results suggest that white blood cells (primarily lymphocytes) are involved in the development of arterial hypertension.

Keywords: SHR rats; WKY rats; arterial hypertension; blood pressure; leukocytes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Blood Pressure
Disease Progression
Hypertension / blood*
Hypertension / physiopathology
Leukocyte Count
Leukocytes / pathology*
Male
Rats
Rats, Inbred SHR
Rats, Inbred WKY