D-ribose-glycation of insulin prevents amyloid aggregation and produces cytotoxic adducts

Biochim Biophys Acta. 2016 Jan;1862(1):93-104. doi: 10.1016/j.bbadis.2015.10.021. Epub 2015 Oct 28.
No abstract available

Keywords: Amyloid aggregation; Apoptosis; D-ribose; Insulin glycation; NF-kB; ROS production.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amyloid / chemistry
  • Amyloid / metabolism*
  • Amyloid / ultrastructure
  • Animals
  • Apoptosis*
  • Cell Survival
  • Glycosylation
  • Humans
  • Insulin / chemistry
  • Insulin / metabolism*
  • Mice
  • NF-kappa B / metabolism
  • NIH 3T3 Cells
  • Protein Aggregation, Pathological / metabolism*
  • Protein Conformation
  • Reactive Oxygen Species / metabolism
  • Ribose / metabolism*

Substances

  • Amyloid
  • Insulin
  • NF-kappa B
  • Reactive Oxygen Species
  • Ribose