Pregnancy outcomes in two growth restricted fetuses with in utero cerebral lactate

N Andescavage; C Limperopoulos; I Evangelou; J Murnick; A du Plessis

doi:10.3233/NPM-15814084

Pregnancy outcomes in two growth restricted fetuses with in utero cerebral lactate

J Neonatal Perinatal Med. 2015;8(3):269-73. doi: 10.3233/NPM-15814084.

Authors

N Andescavage^{1

2}, C Limperopoulos^{2

3

4}, I Evangelou^{2

3

5}, J Murnick^{3

5}, A du Plessis^{2

4}

Affiliations

¹ Children's National Medical Center, Division of Neonatology, Washington, DC, USA.
² George Washington University School of Medicine and Health Sciences, Department of Pediatrics, Washington, DC, USA.
³ Children's National Medical Center, Division of Diagnostic Imaging and Radiology, Washington, DC, USA.
⁴ Children's National Medical Center, Division of Fetal-Transitional Medicine, Washington, DC, USA.
⁵ George Washington University School of Medicine and Health Sciences, Department of Radiology, Washington, DC, USA.

Abstract

Elevated cerebral lactate is increasingly detected by magnetic resonance spectroscopy in the human fetus diagnosed with various pathologic conditions. However, the significance of detectable cerebral lactate remains uncertain. We present two cases of fetal cerebral lactate with adverse pregnancy outcomes.

Keywords: Cerebral lactate; fetal MRI; fetal growth restriction; spectroscopy.

Publication types

Case Reports

MeSH terms

Brain / embryology*
Brain / metabolism*
Fatal Outcome
Female
Fetal Growth Retardation / metabolism*
Fetal Growth Retardation / pathology*
Fetus / metabolism
Humans
Infant, Newborn
Lactic Acid / metabolism*
Magnetic Resonance Spectroscopy
Pregnancy

Substances

Lactic Acid

Grants and funding

L40 HD089314/HD/NICHD NIH HHS/United States