Reprint of localized dose delivering by ion beam irradiation for experimental trial of establishing brain necrosis model

Takushi Takata; Natsuko Kondo; Yoshinori Sakurai; Hiroki Tanaka; Takashi Hasegawa; Kyo Kume; Minoru Suzuki

doi:10.1016/j.apradiso.2015.10.008

Reprint of localized dose delivering by ion beam irradiation for experimental trial of establishing brain necrosis model

Appl Radiat Isot. 2015 Dec:106:104-6. doi: 10.1016/j.apradiso.2015.10.008. Epub 2015 Oct 27.

Authors

Takushi Takata¹, Natsuko Kondo², Yoshinori Sakurai², Hiroki Tanaka², Takashi Hasegawa³, Kyo Kume⁴, Minoru Suzuki²

Affiliations

¹ Research Reactor Institute, Kyoto University, 2 Asashiro-nishi, Kumatori-cho, Sennan-gun, Osaka 590-0494, Japan; The Wakasa Wan Energy Research Center, 64-52-1 Nagatani, Tsuruga-shi, Fukui 914-0192, Japan. Electronic address: taku-takata@rri.kyoto-u.ac.jp.
² Research Reactor Institute, Kyoto University, 2 Asashiro-nishi, Kumatori-cho, Sennan-gun, Osaka 590-0494, Japan.
³ Hase-Tech LLC, 2-10-34-2 Matsushima-cho, Tsuruga-shi, Fukui 914-0801, Japan.
⁴ The Wakasa Wan Energy Research Center, 64-52-1 Nagatani, Tsuruga-shi, Fukui 914-0192, Japan.

PMID: 26515136
DOI: 10.1016/j.apradiso.2015.10.008

Abstract

Localized dose delivery techniques to establish a brain radiation necrosis model are described. An irradiation field was designed by using accelerated protons or helium ions with a spread-out Bragg peak. Measurement of the designed field confirmed that a high dose can be confined to a local volume of an animal brain. The irradiation techniques described here are very useful for establishing a necrosis model without existence of extraneous complications.

Keywords: Accelerated ion beam; Animal model; Brain radiation necrosis; Local volume irradiation; Spread-out Bragg peak.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Brain / pathology
Brain / radiation effects*
Dose-Response Relationship, Radiation*
Necrosis
Radiation Injuries, Experimental / pathology*