Enhancing the efficacy of cation-independent mannose 6-phosphate receptor inhibitors by intracellular delivery

Vipul Agarwal; Priyanka Toshniwal; Natalie E Smith; Nicole M Smith; Binbin Li; Tristan D Clemons; Lindsay T Byrne; Foteini Kakulas; Fiona M Wood; Mark Fear; Ben Corry; K Swaminathan Iyer

doi:10.1039/c5cc06826f

Enhancing the efficacy of cation-independent mannose 6-phosphate receptor inhibitors by intracellular delivery

Chem Commun (Camb). 2016 Jan 7;52(2):327-30. doi: 10.1039/c5cc06826f. Epub 2015 Oct 30.

Authors

Vipul Agarwal¹, Priyanka Toshniwal, Natalie E Smith, Nicole M Smith, Binbin Li, Tristan D Clemons, Lindsay T Byrne, Foteini Kakulas, Fiona M Wood, Mark Fear, Ben Corry, K Swaminathan Iyer

Affiliation

¹ School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia, Australia. swaminatha.iyer@uwa.edu.au.

PMID: 26514404
DOI: 10.1039/c5cc06826f

Abstract

Intracellular delivery of M6P/IGFII receptor inhibitors exhibits better efficacy than extracellular inhibitors to regulate TGFβ1 mediated upregulation of profibrotic marker, collagen I.

Publication types

Research Support, Non-U.S. Gov't