Assessment of Model Based (Input) Impedance, Pulse Wave Velocity, and Wave Reflection in the Asklepios Cohort

Bernhard Hametner; Stephanie Parragh; Christopher Mayer; Thomas Weber; Luc Van Bortel; Marc De Buyzere; Patrick Segers; Ernst Rietzschel; Siegfried Wassertheurer

doi:10.1371/journal.pone.0141656

Assessment of Model Based (Input) Impedance, Pulse Wave Velocity, and Wave Reflection in the Asklepios Cohort

PLoS One. 2015 Oct 29;10(10):e0141656. doi: 10.1371/journal.pone.0141656. eCollection 2015.

Authors

Bernhard Hametner¹, Stephanie Parragh², Christopher Mayer¹, Thomas Weber³, Luc Van Bortel⁴, Marc De Buyzere⁴, Patrick Segers⁵, Ernst Rietzschel⁶, Siegfried Wassertheurer²

Affiliations

¹ Health & Environment Department, AIT Austrian Institute of Technology, Vienna, Austria.
² Health & Environment Department, AIT Austrian Institute of Technology, Vienna, Austria; Department of Analysis & Scientific Computing, Vienna University of Technology, Vienna, Austria.
³ Cardiology Department, Klinikum Wels-Grieskirchen, Wels, Austria.
⁴ Department of Pharmacology, Ghent University, Ghent, Belgium.
⁵ Institute of Biomedical Technology, iMinds Medical IT, Ghent University, Ghent, Belgium.
⁶ Department of Internal Medicine, Ghent University, Ghent, Belgium.

Abstract

Objectives: Arterial stiffness and wave reflection parameters assessed from both invasive and non-invasive pressure and flow readings are used as surrogates for ventricular and vascular load. They have been reported to predict adverse cardiovascular events, but clinical assessment is laborious and may limit widespread use. This study aims to investigate measures of arterial stiffness and central hemodynamics provided by arterial tonometry alone and in combination with aortic root flows derived by echocardiography against surrogates derived by a mathematical pressure and flow model in a healthy middle-aged cohort.

Methods: Measurements of carotid artery tonometry and echocardiography were performed on 2226 ASKLEPIOS study participants and parameters of systemic hemodynamics, arterial stiffness and wave reflection based on pressure and flow were measured. In a second step, the analysis was repeated but echocardiography derived flows were substituted by flows provided by a novel mathematical model. This was followed by a quantitative method comparison.

Results: All investigated parameters showed a significant association between the methods. Overall agreement was acceptable for all parameters (mean differences: -0.0102 (0.033 SD) mmHg*s/ml for characteristic impedance, 0.36 (4.21 SD) mmHg for forward pressure amplitude, 2.26 (3.51 SD) mmHg for backward pressure amplitude and 0.717 (1.25 SD) m/s for pulse wave velocity).

Conclusion: The results indicate that the use of model-based surrogates in a healthy middle aged cohort is feasible and deserves further attention.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Carotid Arteries / physiology*
Carotid Arteries / physiopathology*
Cohort Studies
Echocardiography
Electric Impedance*
Female
Hemodynamics
Humans
Longitudinal Studies
Male
Manometry
Middle Aged
Models, Biological*
Pulse Wave Analysis*
Vascular Stiffness*

Grants and funding

This work and its publication were partly supported by a grant from the government of Lower Austria and the EC (EFRD), contract number WST3-T-81/015-2008. All other costs were covered by internal funding from the AIT Austrian Institute of Technology.