The Regulatory T Cell: Jack-Of-All-Trades

Ajithkumar Vasanthakumar; Axel Kallies

doi:10.1016/j.it.2015.10.002

The Regulatory T Cell: Jack-Of-All-Trades

Trends Immunol. 2015 Dec;36(12):756-758. doi: 10.1016/j.it.2015.10.002. Epub 2015 Oct 25.

Authors

Ajithkumar Vasanthakumar¹, Axel Kallies²

Affiliations

¹ The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, 3052, Australia; The Department of Medical Biology, University of Melbourne, Parkville, Victoria, 3010, Australia.
² The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, 3052, Australia; The Department of Medical Biology, University of Melbourne, Parkville, Victoria, 3010, Australia. Electronic address: kallies@wehi.edu.au.

PMID: 26511762
DOI: 10.1016/j.it.2015.10.002

Abstract

Foxp3(+) regulatory T (Treg) cells suppress auto-reactive and inflammatory T cells to maintain immune homeostasis. In a recent study, Rudensky and colleagues demonstrate the ability of Treg cells to facilitate tissue repair, a non-canonical Treg cell function accomplished by amphiregulin and mediated by cytokines interleukin (IL)-18 and IL-33.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Humans
Influenza, Human / immunology*
Lung / cytology*
T-Lymphocytes, Regulatory / cytology*
T-Lymphocytes, Regulatory / immunology*