P16 and HPV discordance in metastatic carcinoma of cervical lymph nodes of unknown primary

Alyssa Ralph; Andrew Meyer; Ronald Sirota; Arthur Hooberman

doi:10.1002/ccr3.338

P16 and HPV discordance in metastatic carcinoma of cervical lymph nodes of unknown primary

Clin Case Rep. 2015 Oct;3(10):817-8. doi: 10.1002/ccr3.338. Epub 2015 Sep 2.

Authors

Alyssa Ralph¹, Andrew Meyer², Ronald Sirota³, Arthur Hooberman²

Affiliations

¹ Department of Medicine, Advocate Lutheran General Hospital Park Ridge, Chicago, Illinois, 60068, USA.
² Division of Hematology and Oncology, Advocate Lutheran General Hospital Park Ridge, Chicago, Illinois, 60068, USA.
³ Division of Pathology, Advocate Lutheran General Hospital Park Ridge, Chicago, Illinois, 60068, USA.

Abstract

The prognostic utility of HPV in oropharyngeal squamous cell carcinoma (OPSCC) and non-OPSCC as has been well documented. Currently, a standardized IHC scoring system does not exist and is needed to define HPV positivity. We have recently seen a patient that provides a caution in using p16 status as a diagnostic aid.

Keywords: HPV; Oropharyngeal squamous cell carcinoma; P16; Unknown primary.

Publication types

Case Reports