Adenovirus necrotizing hepatitis complicating atypical teratoid rhabdoid tumor

Pediatr Int. 2015 Oct;57(5):974-7. doi: 10.1111/ped.12674. Epub 2015 Aug 19.

Abstract

Adenovirus-induced fulminant hepatitis is rare. It has been reported in children with primary immunodeficiency, following transplantation or while receiving chemotherapy for hematological malignancy. We present the case of an infant recovering from chemotherapy for atypical teratoid rhabdoid tumor (ATRT) in whom a diagnosis of hepatic necrosis due to adenovirus was made.

Keywords: adenovirus; atypical teratoid/rhabdoid tumor; cidofovir; hepatic necrosis.

Publication types

  • Case Reports

MeSH terms

  • Adenoviridae / genetics
  • Adenoviridae / isolation & purification*
  • Biopsy
  • Brain Neoplasms / complications*
  • Brain Neoplasms / diagnosis
  • DNA, Viral / analysis
  • Fatal Outcome
  • Hepatitis, Viral, Human / diagnosis
  • Hepatitis, Viral, Human / etiology*
  • Hepatitis, Viral, Human / virology
  • Humans
  • Infant
  • Liver / pathology*
  • Liver / virology
  • Magnetic Resonance Imaging
  • Male
  • Microscopy, Electron
  • Necrosis
  • Polymerase Chain Reaction
  • Rhabdoid Tumor / complications*
  • Rhabdoid Tumor / diagnosis
  • Teratoma / complications*
  • Teratoma / diagnosis

Substances

  • DNA, Viral

Supplementary concepts

  • Typical Teratoid Rhabdoid Tumor