Cochrane Corner: Colchicine in acute and recurrent pericarditis
Rev Port Cardiol. 2015 Nov;34(11):697-9.
doi: 10.1016/j.repc.2015.03.023.
Epub 2015 Oct 23.
[Article in
English,
Portuguese]
Affiliations
- 1 Laboratório de Farmacologia Clínica e Terapêutica, Faculdade de Medicina da Universidade de Lisboa, Portugal; Unidade de Farmacologia Clínica, Instituto de Medicina Molecular, Lisboa, Portugal; Serviço de Cardiologia, Hospital Garcia de Orta, Almada, Portugal. Electronic address: dgcaldeira@hotmail.com.
- 2 Centro de Estudos de Medicina Baseada na Evidência, Faculdade de Medicina da Universidade de Lisboa, Portugal; Centro Colaborador Português da Rede Cochrane Iberoamericana, Lisboa, Portugal.
- 3 Laboratório de Farmacologia Clínica e Terapêutica, Faculdade de Medicina da Universidade de Lisboa, Portugal; Unidade de Farmacologia Clínica, Instituto de Medicina Molecular, Lisboa, Portugal; Centro de Estudos de Medicina Baseada na Evidência, Faculdade de Medicina da Universidade de Lisboa, Portugal; Centro Colaborador Português da Rede Cochrane Iberoamericana, Lisboa, Portugal.
Abstract
The potential anti-inflammatory effect of colchicine has been explored in many conditions, including pericarditis. The Cochrane Collaboration Systematic Review included four randomized controlled trials enrolling 564 patients with acute pericarditis (two studies) or recurrent pericarditis (two studies), followed for a period of 20-24 months. Colchicine was associated with a significant reduction in short-term persistence of chest pain and in long-term risk of recurrence of pericarditis. No significant increase in overall adverse events was observed. Despite the available evidence, the use of colchicine in this context remains strictly off-label.
Keywords:
Chest pain; Colchicina; Colchicine; Dor torácica; Pericardite; Pericarditis.
Copyright © 2015 Sociedade Portuguesa de Cardiologia. Published by Elsevier España. All rights reserved.
MeSH terms
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Colchicine / therapeutic use*
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Humans
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Pericarditis / drug therapy*
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Randomized Controlled Trials as Topic
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Recurrence
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Review Literature as Topic
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Tubulin Modulators / therapeutic use*
Substances
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Tubulin Modulators
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Colchicine