SPOP the mutation

Elife. 2015 Oct 27:4:e11760. doi: 10.7554/eLife.11760.

Abstract

Prostate cancers with mutations to a protein called SPOP use an error-prone method to repair broken DNA strands.

Keywords: DNA repair; SPOP; cancer genomics; cell biology; human; human biology; medicine; mouse; prostate cancer; zebrafish.

Publication types

  • Comment

MeSH terms

  • Animals
  • Genomic Instability*
  • Humans
  • Male
  • Nuclear Proteins / deficiency*
  • Prostatic Neoplasms / pathology*
  • Repressor Proteins / deficiency*

Substances

  • Nuclear Proteins
  • Repressor Proteins