Fluconazole exposure during pregnancy

Can Fam Physician. 2015 Aug;61(8):685-6.

Abstract

Question: One of my patients has just learned that she is 8 weeks pregnant. She took a 150-mg dose of fluconazole 2 weeks ago for the treatment of vaginal candidiasis and she is worried about the effect on her child and pregnancy. Can I reassure her?

Answer: Short-term and low-dose fluconazole exposure, such as that indicated in the treatment of vaginal candidiasis, is not expected to increase the overall risk of major congenital malformations.

Question L’une de mes patientes vient tout juste d’apprendre qu’elle est enceinte de 8 semaines. Elle a pris une dose de 150 mg de fluconazole il y a 2 semaines pour traiter une candidose vaginale et s’inquiète des répercussions sur son enfant et sa grossesse. Puis-je la rassurer?

Réponse L’exposition de courte durée et à faible dose au fluconazole, comme celle indiquée dans le traitement de la candidose vaginale, ne devrait pas augmenter le risque général de malformations congénitales majeures.

MeSH terms

  • Abnormalities, Drug-Induced / epidemiology*
  • Abnormalities, Drug-Induced / etiology
  • Antifungal Agents / therapeutic use*
  • Candidiasis, Vulvovaginal / drug therapy*
  • Female
  • Fluconazole / therapeutic use*
  • Humans
  • Pregnancy
  • Pregnancy Complications, Infectious / drug therapy*
  • Prenatal Exposure Delayed Effects / chemically induced
  • Prenatal Exposure Delayed Effects / epidemiology*

Substances

  • Antifungal Agents
  • Fluconazole