A two-photon fluorescent probe for lysosomal zinc ions

Chem Commun (Camb). 2016 Jan 4;52(1):124-7. doi: 10.1039/c5cc06976a.

Abstract

The selective detection of zinc ions in lysosomes over that in cytosol is achieved with a fluorescent probe, which enabled the fluorescence imaging of endogenous zinc ions in lysosomes of NIH 3T3 cells as well as mouse hippocampal tissues by two-photon microscopy under excitation at 900 nm.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cations, Divalent / analysis
  • Fluorescent Dyes / chemistry*
  • Hippocampus / chemistry*
  • Lysosomes / chemistry*
  • Mice
  • Microscopy, Fluorescence
  • NIH 3T3 Cells
  • Optical Imaging
  • Zinc / analysis*

Substances

  • Cations, Divalent
  • Fluorescent Dyes
  • Zinc