Data in support of quantitative proteomics to identify potential virulence regulators in Paracoccidioides brasiliensis isolates

Alexandre Keiji Tashima; Daniele Gonçalves Castilho; Alison Felipe Alencar Chaves; Patricia Xander; André Zelanis; Wagner Luiz Batista

doi:10.1016/j.dib.2015.09.001

Data in support of quantitative proteomics to identify potential virulence regulators in Paracoccidioides brasiliensis isolates

Data Brief. 2015 Sep 9:5:155-60. doi: 10.1016/j.dib.2015.09.001. eCollection 2015 Dec.

Authors

Alexandre Keiji Tashima¹, Daniele Gonçalves Castilho², Alison Felipe Alencar Chaves², Patricia Xander³, André Zelanis⁴, Wagner Luiz Batista⁵

Affiliations

¹ Departamento de Bioquímica, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
² Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
³ Departamento de Ciências Biológicas, Universidade Federal de São Paulo, Campus Diadema, Diadema, SP, Brazil.
⁴ Instituto de Ciência e Tecnologia, Universidade Federal de São Paulo, Campus São José dos Campos, Rua Talim, 330, São José dos Campos, SP, Brazil.
⁵ Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil ; Departamento de Ciências Biológicas, Universidade Federal de São Paulo, Campus Diadema, Diadema, SP, Brazil.

Abstract

Paracoccidioides genus are the etiologic agents of paracoccidioidomycosis (PCM), a systemic mycosis endemic in Latin America. Few virulence factors have been identified in these fungi. This paper describes support data from the quantitative proteomics of Paracoccidioides brasiliensis attenuated and virulent isolates [1]. The protein compositions of two isolates of the Pb18 strain showing distinct infection profiles were quantitatively assessed by stable isotopic dimethyl labeling and proteomic analysis. The mass spectrometry and the analysis dataset have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with identifier PXD000804.

Keywords: Paracoccidioides brasiliensis; Pathogenic fungus; Proteomic analysis; Virulence factors.