Self-assembly of the anti-fungal polyene amphotericin B into giant helically-twisted nanotapes

Ian William Hamley; Steven Kirkham; Radoslaw M Kowalczyk; Valeria Castelletto; Mehedi Reza; Janne Ruokolainen

doi:10.1039/c5cc08224b

Self-assembly of the anti-fungal polyene amphotericin B into giant helically-twisted nanotapes

Chem Commun (Camb). 2015 Dec 28;51(100):17680-3. doi: 10.1039/c5cc08224b.

Authors

Ian William Hamley¹, Steven Kirkham¹, Radoslaw M Kowalczyk¹, Valeria Castelletto¹, Mehedi Reza², Janne Ruokolainen²

Affiliations

¹ School of Chemistry, Pharmacy and Food Biosciences, University of Reading, Whiteknights, Reading, Berkshire RG6 6AD, UK. i.w.hamley@reading.ac.uk.
² Dept. of Applied Physics, Aalto University School of Science, P. O. Box 15100, FI-00076, Finland.

PMID: 26499063
DOI: 10.1039/c5cc08224b

Abstract

The amphiphilic polyene amphotericin B, a powerful treatment for systemic fungal infections, is shown to exhibit a critical aggregation concentration, and to form giant helically-twisted nanostructures via self-assembly in basic aqueous solution.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amphotericin B / chemistry*
Antifungal Agents / chemistry*
Circular Dichroism
Fluorescence
Hydrogen-Ion Concentration
Kinetics
Macromolecular Substances / chemistry*
Nanofibers / chemistry*
Stereoisomerism
X-Ray Diffraction

Substances

Antifungal Agents
Macromolecular Substances
Amphotericin B