Abstract
Simple dissolution of an arylalkyl acid chloride in 1,1,1,3,3,3-hexafluoro-2-propanol promotes an intramolecular Friedel-Crafts acylation without additional catalysts or reagents. This reaction is operationally trivial in both execution and product isolation (only requiring concentration followed by purification) and accommodates a broad range of substrates. Preliminary studies that bear upon potential reaction mechanisms are reported.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Acylation
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Catalysis
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Hydrocarbons, Chlorinated / chemical synthesis*
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Hydrocarbons, Chlorinated / chemistry*
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Indoles / chemical synthesis*
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Indoles / chemistry
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Molecular Structure
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Propanols / chemistry*
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Stereoisomerism
Substances
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Hydrocarbons, Chlorinated
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Indoles
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Propanols
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hexafluoroisopropanol