Two cases of ameloblastoma treated in part by cryotherapy have been presented. The first case was of particular interest because of the extensive intraoral involvement and history of recurrences. The second case evolved as an example of the rare peripheral ameloblastoma. In both cases, cryotherapy was used as an adjunctive modality to conserve mandibular bone without compromising the primary objective of adequately treating the tumor. We contend that the judicious use of cryotherapy offers the advantage of treating a broad area of bone without destruction of the basic structural matrix of this tissue.