Association Study between the FTCDNL1 (FONG) and Susceptibility to Osteoporosis

PLoS One. 2015 Oct 22;10(10):e0140549. doi: 10.1371/journal.pone.0140549. eCollection 2015.

Abstract

Osteoporosis is a systemic skeletal disease characterized by a decreased bone mineral density that results in an increased risk of fragility fractures. Previous studies indicated that genetic factors are involved in the pathogenesis of osteoporosis. Polymorphisms of the FONG (FTCDNL1) gene (rs7605378) were reported to be associated with the risk of osteoporosis in a Japanese population. To assess whether polymorphisms of the FTCDNL1 gene contribute to the susceptibility and severity of osteoporosis in a Taiwanese population, 326 osteoporosis patients and 595 controls of a Taiwanese population were included in this study. Our results indicated that rs10203122 was significantly associated with osteoporosis susceptibility among female. Our findings provide evidence that rs10203122 in FTCDNL1 is associated with a susceptibility to osteoporosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Bone Density / genetics
  • Bone and Bones / pathology
  • Case-Control Studies
  • Demography
  • Female
  • Genetic Association Studies*
  • Genetic Predisposition to Disease*
  • Haplotypes / genetics
  • Humans
  • Hydroxymethyl and Formyl Transferases / genetics*
  • Linkage Disequilibrium / genetics
  • Male
  • Osteoporosis / genetics*
  • Polymorphism, Single Nucleotide / genetics*
  • Risk Factors

Substances

  • FTCDNL1 protein, human
  • Hydroxymethyl and Formyl Transferases

Grants and funding

Funded by Comprehensive Cancer Center of Taipei Medical University/Health and welfare surcharge of tobacco products (MOHW103-TD-B-111-01). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.