Optimal timing of [¹⁸F]Mefway PET for imaging the serotonin 1A receptor in healthy male subjects

Appl Radiat Isot. 2016 Jan:107:127-132. doi: 10.1016/j.apradiso.2015.10.004. Epub 2015 Oct 9.

Abstract

To determine the optimal acquisition time of [(18)F]Mefway PET, we examined the regional specific-to-nonspecific binding ratios and evaluated the relationship between distribution volume ratios (DVRs) and standardized uptake value ratios (SUVRs) in various time windows. The specific-to-nonspecific binding ratios peaked after 40 min and there was a strong correlation between DVR and SUVR in the 60-80 min. Therefore, we recommend the use of a single time point between 60 and 80 min for [(18)F]Mefway static PET.

Keywords: Optimal acquisition time; Positron emission tomography; Serotonin 1A receptor; Standardized uptake value ratio; [(18)F]Mefway.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Fluorine Radioisotopes* / pharmacokinetics
  • Humans
  • Male
  • Multimodal Imaging
  • Piperazines* / pharmacokinetics
  • Positron-Emission Tomography / methods*
  • Positron-Emission Tomography / statistics & numerical data
  • Pyridines* / pharmacokinetics
  • Radiopharmaceuticals* / pharmacokinetics
  • Receptor, Serotonin, 5-HT1A / metabolism*
  • Reference Values
  • Tomography, X-Ray Computed
  • Young Adult

Substances

  • Fluorine Radioisotopes
  • Piperazines
  • Pyridines
  • Radiopharmaceuticals
  • mefway
  • Receptor, Serotonin, 5-HT1A