Abstract
We investigated 16S rRNA methyltransferases in 38 blaNDM-1-positive Pseudomonas aeruginosa isolates and found RmtC in 3 isolates, 1 of which also harbored RmtF. The isolates were clonally unrelated; rmtC and rmtF genes were located on a chromosome with the blaNDM-1 gene. Strategies are needed to limit the spread of such isolates.
Keywords:
India; Lucknow; NDM-1; Pseudomonas aeruginosa; aminoglycosides; antimicrobial resistance; bacteria; imipenem; meropenem; methyltransferases.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Bacterial Proteins / genetics*
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DNA, Bacterial
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Drug Resistance, Multiple, Bacterial / genetics*
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Gene Expression Regulation, Bacterial
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Humans
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Methyltransferases / genetics*
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Methyltransferases / metabolism
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Pseudomonas aeruginosa / drug effects
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Pseudomonas aeruginosa / genetics*
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RNA, Ribosomal, 16S / metabolism*
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beta-Lactamases / metabolism
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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DNA, Bacterial
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RNA, Ribosomal, 16S
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Methyltransferases
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rRNA (adenosine-O-2'-)methyltransferase
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beta-Lactamases
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beta-lactamase NDM-1