RmtC and RmtF 16S rRNA Methyltransferase in NDM-1-Producing Pseudomonas aeruginosa

Emerg Infect Dis. 2015 Nov;21(11):2059-62. doi: 10.3201/eid2111.150271.

Abstract

We investigated 16S rRNA methyltransferases in 38 blaNDM-1-positive Pseudomonas aeruginosa isolates and found RmtC in 3 isolates, 1 of which also harbored RmtF. The isolates were clonally unrelated; rmtC and rmtF genes were located on a chromosome with the blaNDM-1 gene. Strategies are needed to limit the spread of such isolates.

Keywords: India; Lucknow; NDM-1; Pseudomonas aeruginosa; aminoglycosides; antimicrobial resistance; bacteria; imipenem; meropenem; methyltransferases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Bacterial Proteins / genetics*
  • DNA, Bacterial
  • Drug Resistance, Multiple, Bacterial / genetics*
  • Gene Expression Regulation, Bacterial
  • Humans
  • Methyltransferases / genetics*
  • Methyltransferases / metabolism
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • Pseudomonas aeruginosa / drug effects
  • Pseudomonas aeruginosa / genetics*
  • RNA, Ribosomal, 16S / metabolism*
  • beta-Lactamases / metabolism

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • DNA, Bacterial
  • RNA, Ribosomal, 16S
  • Methyltransferases
  • rRNA (adenosine-O-2'-)methyltransferase
  • beta-Lactamases
  • beta-lactamase NDM-1