Fosfomycin Resistance in Escherichia coli, Pennsylvania, USA

Emerg Infect Dis. 2015 Nov;21(11):2045-7. doi: 10.3201/eid2111.150750.

Abstract

Fosfomycin resistance in Escherichia coli is rare in the United States. An extended-spectrum β-lactamase-producing E. coli clinical strain identified in Pennsylvania, USA, showed high-level fosfomycin resistance caused by the fosA3 gene. The IncFII plasmid carrying this gene had a structure similar to those found in China, where fosfomycin resistance is commonly described.

Keywords: 16S rRNA methyltransferase; ESBL; Escherichia coli; Pennsylvania; United States; antimicrobial resistance; bacteria; extended-spectrum β-lactamase; fosA3 gene; fosfomycin resistance; glutathione S-transferase; plasmids.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Drug Resistance, Bacterial / genetics*
  • Escherichia coli / genetics
  • Escherichia coli / immunology*
  • Escherichia coli Infections / drug therapy
  • Escherichia coli Infections / epidemiology
  • Female
  • Fosfomycin / immunology*
  • Fosfomycin / pharmacology*
  • Humans
  • Pennsylvania / epidemiology
  • Sequence Analysis, DNA / statistics & numerical data

Substances

  • Anti-Bacterial Agents
  • Fosfomycin