Abstract
Thirteen new hydroxylated calyciphylline A-type Daphniphyllum alkaloids (1-13) were isolated from an ethanolic extract of Daphniphyllum himalense. These structures were characterized on the basis of spectroscopic data analysis, especially from their 2D NMR spectra. Oxidation at the C-3, C-9, C-11, and C-12 positions is reported for the first time for this class of compounds. Selective compounds showed low inhibitory rates against three kinase enzymes, PTP1B, aurora A, and IKK-β, at a concentration of 20 μg/mL.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Aurora Kinase A / antagonists & inhibitors
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I-kappa B Kinase / antagonists & inhibitors
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Magnoliopsida / chemistry*
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Molecular Structure
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Nepal
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Nuclear Magnetic Resonance, Biomolecular
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Plant Leaves / chemistry
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Plant Stems / chemistry
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Protein Tyrosine Phosphatase, Non-Receptor Type 1 / antagonists & inhibitors
Substances
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Alkaloids
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Aurora Kinase A
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I-kappa B Kinase
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PTPN1 protein, human
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Protein Tyrosine Phosphatase, Non-Receptor Type 1