Hydroxylated Daphniphyllum Alkaloids from Daphniphyllum himalense

J Nat Prod. 2015 Nov 25;78(11):2761-7. doi: 10.1021/acs.jnatprod.5b00741. Epub 2015 Oct 21.

Abstract

Thirteen new hydroxylated calyciphylline A-type Daphniphyllum alkaloids (1-13) were isolated from an ethanolic extract of Daphniphyllum himalense. These structures were characterized on the basis of spectroscopic data analysis, especially from their 2D NMR spectra. Oxidation at the C-3, C-9, C-11, and C-12 positions is reported for the first time for this class of compounds. Selective compounds showed low inhibitory rates against three kinase enzymes, PTP1B, aurora A, and IKK-β, at a concentration of 20 μg/mL.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology
  • Aurora Kinase A / antagonists & inhibitors
  • I-kappa B Kinase / antagonists & inhibitors
  • Magnoliopsida / chemistry*
  • Molecular Structure
  • Nepal
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Leaves / chemistry
  • Plant Stems / chemistry
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1 / antagonists & inhibitors

Substances

  • Alkaloids
  • Aurora Kinase A
  • I-kappa B Kinase
  • PTPN1 protein, human
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1