Photonic hydrogel sensors

Ali K Yetisen; Haider Butt; Lisa R Volpatti; Ida Pavlichenko; Matjaž Humar; Sheldon J J Kwok; Heebeom Koo; Ki Su Kim; Izabela Naydenova; Ali Khademhosseini; Sei Kwang Hahn; Seok Hyun Yun

doi:10.1016/j.biotechadv.2015.10.005

Photonic hydrogel sensors

Biotechnol Adv. 2016 May-Jun;34(3):250-71. doi: 10.1016/j.biotechadv.2015.10.005. Epub 2015 Oct 17.

Authors

Affiliations

¹ Harvard Medical School, Wellman Center for Photomedicine, Massachusetts General Hospital, 65 Landsdowne Street, Cambridge, MA 02139, USA. Electronic address: ayetisen@mgh.harvard.edu.
² School of Mechanical Engineering, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.
³ Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
⁴ School of Engineering and Applied Sciences, Harvard University, 9 Oxford Street, Cambridge, MA 02139, USA.
⁵ Harvard Medical School, Wellman Center for Photomedicine, Massachusetts General Hospital, 65 Landsdowne Street, Cambridge, MA 02139, USA; Condensed Matter Department, J. Stefan Institute, Jamova 39, SI-1000 Ljubljana, Slovenia.
⁶ Harvard Medical School, Wellman Center for Photomedicine, Massachusetts General Hospital, 65 Landsdowne Street, Cambridge, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
⁷ Harvard Medical School, Wellman Center for Photomedicine, Massachusetts General Hospital, 65 Landsdowne Street, Cambridge, MA 02139, USA.
⁸ Centre for Industrial and Engineering Optics, School of Physics, College of Sciences and Health, Dublin Institute of Technology, Dublin 8, Ireland.
⁹ Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Biomaterials Innovation Research Center, Division of Biomedical Engineering, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA; Department of Physics, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Bioindustrial Technologies, College of Animal Bioscience and Technology, Konkuk University, Hwayang-dong, Gwangjin-gu, Seoul 143-701, Republic of Korea.
¹⁰ Department of Materials Science & Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Kyungbuk 790-784, Republic of Korea.
¹¹ Harvard Medical School, Wellman Center for Photomedicine, Massachusetts General Hospital, 65 Landsdowne Street, Cambridge, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: syun@mgh.harvard.edu.

PMID: 26485407
DOI: 10.1016/j.biotechadv.2015.10.005

Abstract

Analyte-sensitive hydrogels that incorporate optical structures have emerged as sensing platforms for point-of-care diagnostics. The optical properties of the hydrogel sensors can be rationally designed and fabricated through self-assembly, microfabrication or laser writing. The advantages of photonic hydrogel sensors over conventional assay formats include label-free, quantitative, reusable, and continuous measurement capability that can be integrated with equipment-free text or image display. This Review explains the operation principles of photonic hydrogel sensors, presents syntheses of stimuli-responsive polymers, and provides an overview of qualitative and quantitative readout technologies. Applications in clinical samples are discussed, and potential future directions are identified.

Keywords: Block copolymers; Bragg stacks; Crystalline colloidal arrays; Holography; Hydrogels; In vitro diagnostics; Inverse opals; Layer-by-layer deposition; Photonic crystals; Plasmonics.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Equipment Design
Hydrogels*
Photons*
Point-of-Care Systems

Substances

Hydrogels