Gene expression analysis of laryngeal squamous cell carcinoma

Jessica Rodrigues Plaça; Rafaela de Barros E Lima Bueno; Daniel Guariz Pinheiro; Rodrigo Alexandre Panepucci; Luiza Ferreira de Araújo; Rui Celso Martins Mamede; David Livingstone Alves Figueiredo; Wilson Araújo Silva Jr

doi:10.1016/j.gdata.2015.04.024

Gene expression analysis of laryngeal squamous cell carcinoma

Genom Data. 2015 May 8:5:9-12. doi: 10.1016/j.gdata.2015.04.024. eCollection 2015 Sep.

Authors

Jessica Rodrigues Plaça¹, Rafaela de Barros E Lima Bueno², Daniel Guariz Pinheiro³, Rodrigo Alexandre Panepucci⁴, Luiza Ferreira de Araújo², Rui Celso Martins Mamede⁵, David Livingstone Alves Figueiredo⁶, Wilson Araújo Silva Jr⁷

Affiliations

¹ National Institute of Science and Technology in Stem Cell and Cell Therapy and Center For Cell-Based Therapy, Rua Tenente Catão Roxo, 2501, Monte Alegre, Ribeirão Preto, SP CEP 14051-140, Brazil ; Center for Integrative Systems Biology, CISBi, NAP/USP, Rua Catão Roxo, 2501, Monte Alegre, Ribeirão Preto, SP CEP 14051-140, Brazil.
² Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes 3900, Monte Alegre, Ribeirão Preto, SP CEP 14049-900, Brazil ; National Institute of Science and Technology in Stem Cell and Cell Therapy and Center For Cell-Based Therapy, Rua Tenente Catão Roxo, 2501, Monte Alegre, Ribeirão Preto, SP CEP 14051-140, Brazil.
³ Department of Technology, College of Agriculture and Veterinary Sciences, UNESP, Via de acesso Prof. Paulo Donato Castellane, s/n, Jaboticabal, SP CEP 14884-900, Brazil.
⁴ National Institute of Science and Technology in Stem Cell and Cell Therapy and Center For Cell-Based Therapy, Rua Tenente Catão Roxo, 2501, Monte Alegre, Ribeirão Preto, SP CEP 14051-140, Brazil.
⁵ Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes 3900, Monte Alegre, Ribeirão Preto, SP CEP 14049-900, Brazil.
⁶ University of Centro-Oeste, Rua Padre Salvador, 875, Santa Cruz, Guarapuava, PR CEP 85015-430, Brazil.
⁷ Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes 3900, Monte Alegre, Ribeirão Preto, SP CEP 14049-900, Brazil ; National Institute of Science and Technology in Stem Cell and Cell Therapy and Center For Cell-Based Therapy, Rua Tenente Catão Roxo, 2501, Monte Alegre, Ribeirão Preto, SP CEP 14051-140, Brazil ; Center for Integrative Systems Biology, CISBi, NAP/USP, Rua Catão Roxo, 2501, Monte Alegre, Ribeirão Preto, SP CEP 14051-140, Brazil.

Abstract

Laryngeal squamous cell carcinoma (LSCC) is one of the most common malignancies of the head and neck tumors Zhang et al., 2013 [1]). Previous studies have associated its occurrence with social activities, such as tobacco and alcohol consumption (Hashibe et al., 2007a [2]; Hashibe et al., 2007b [3]; Shangina et al., 2006 [4]). Here, we performed a genome-wide gene expression profiling in thirty-one patients positively diagnosed for LSCC, in order to investigate new targets involved in tumorigenesis.

Keywords: Gene expression profile; Laryngeal squamous cell carcinoma tumor; Microarray.