Multipotent human stromal cells isolated from cord blood, term placenta and adult bone marrow show distinct differences in gene expression pattern

Nicholas Matigian; Gary Brooke; Faten Zaibak; Tony Rossetti; Katarina Kollar; Rebecca Pelekanos; Celena Heazlewood; Alan Mackay-Sim; Christine A Wells; Kerry Atkinson

doi:10.1016/j.gdata.2014.11.011

Multipotent human stromal cells isolated from cord blood, term placenta and adult bone marrow show distinct differences in gene expression pattern

Genom Data. 2014 Nov 28:3:70-4. doi: 10.1016/j.gdata.2014.11.011. eCollection 2015 Mar.

Affiliations

¹ Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, 4072, Australia ; Eskitis Institute for Drug Discovery, National Centre for Adult Stem Cell Research, Griffith University, Brisbane, 4111, Australia.
² Mater Medical Research Institute, University of Queensland, Woolloongabba, Brisbane, 4102, Australia.
³ Murdoch Children's Research Institute, The University of Melbourne, Royal Children's Hospital, Parkville, Victoria, 3052, Australia.
⁴ Eskitis Institute for Drug Discovery, National Centre for Adult Stem Cell Research, Griffith University, Brisbane, 4111, Australia.
⁵ Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, 4072, Australia ; Eskitis Institute for Drug Discovery, National Centre for Adult Stem Cell Research, Griffith University, Brisbane, 4111, Australia ; The Institute for Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, The University of Glasgow, Scotland, G12 8TA, UK.

Abstract

Multipotent mesenchymal stromal cells derived from human placenta (pMSCs), and unrestricted somatic stem cells (USSCs) derived from cord blood share many properties with human bone marrow-derived mesenchymal stromal cells (bmMSCs) and are currently in clinical trials for a wide range of clinical settings. Here we present gene expression profiles of human cord blood-derived unrestricted somatic stem cells (USSCs), human placental-derived mesenchymal stem cells (hpMSCs), and human bone marrow-derived mesenchymal stromal cells (bmMSCs), all derived from four different donors. The microarray data are available on the ArrayExpress database (www.ebi.ac.uk/arrayexpress) under accession number E-TABM-880. Additionally, the data has been integrated into a public portal, www.stemformatics.org. Our data provide a resource for understanding the differences in MSCs derived from different tissues.

Keywords: Mesenchymal stem cells; Mesenchymal stromal cells; Multipotent human stromal cells.