Global transcriptional analysis of short-term hepatic stress responses in Atlantic salmon (Salmo salar) exposed to depleted uranium

You Song; Brit Salbu; Hans-Christian Teien; Lene Sørlie Heier; Bjørn Olav Rosseland; Tore Høgåsen; Knut Erik Tollefsen

doi:10.1016/j.gdata.2014.10.003

Global transcriptional analysis of short-term hepatic stress responses in Atlantic salmon (Salmo salar) exposed to depleted uranium

Genom Data. 2014 Oct 7:2:340-1. doi: 10.1016/j.gdata.2014.10.003. eCollection 2014 Dec.

Authors

You Song¹, Brit Salbu², Hans-Christian Teien², Lene Sørlie Heier², Bjørn Olav Rosseland³, Tore Høgåsen⁴, Knut Erik Tollefsen¹

Affiliations

¹ Norwegian University of Life Sciences (NMBU), Centre for Environmental Radioactivity (CERAD), Faculty of Environmental Science and Technology, Department of Environmental Sciences (IMV), P.O. Box 5003, N-1432 Ås, Norway ; Norwegian Institute for Water Research (NIVA), Section of Ecotoxicology and Risk Assessment, Gaustadalléen 21, N-0349 Oslo, Norway.
² Norwegian University of Life Sciences (NMBU), Centre for Environmental Radioactivity (CERAD), Faculty of Environmental Science and Technology, Department of Environmental Sciences (IMV), P.O. Box 5003, N-1432 Ås, Norway.
³ Norwegian University of Life Sciences (NMBU), Centre for Environmental Radioactivity (CERAD), Faculty of Environmental Science and Technology, Department of Environmental Sciences (IMV), P.O. Box 5003, N-1432 Ås, Norway ; Norwegian University of Life Sciences (NMBU), Faculty of Environmental Science and Technology, Department of Ecology and Natural Resource Management, P.O. Box 5003, N-1432 Ås, Norway.
⁴ Norwegian Institute for Water Research (NIVA), Section of Ecotoxicology and Risk Assessment, Gaustadalléen 21, N-0349 Oslo, Norway.

Abstract

Potential environmental hazards of radionuclides are often studied at the individual level. Sufficient toxicogenomics data at the molecular/cellular level for understanding the effects and modes of toxic action (MoAs) of radionuclide is still lacking. The current article introduces transcriptomic data generated from a recent ecotoxicological study, with the aims to characterize the MoAs of a metallic radionuclide, deplete uranium (DU) in an ecologically and commercially important fish species, Atlantic salmon (Salmo salar). Salmon were exposed to three concentrations (0.25, 0.5 and 1.0 mg/L) of DU for 48 h. Short-term global transcriptional responses were studied using Agilent custom-designed high density 60,000-feature (60 k) salmonid oligonucleotide microarrays (oligoarray). The microarray datasets deposited at Gene Expression Omnibus (GEO ID: GSE58824) were associated with a recently published study by Song et al. (2014) in BMC Genomics. The authors describe the experimental data herein to build a platform for better understanding the toxic mechanisms and ecological hazard of radionuclides such as DU in fish.

Keywords: Atlantic salmon; Depleted uranium; Gene expression; Microarray; Stress response.