Pontemazines A and B, phenazine derivatives containing a methylamine linkage from Streptomyces sp. UT1123 and their protective effect to HT-22 neuronal cells

Bioorg Med Chem Lett. 2015 Nov 15;25(22):5083-6. doi: 10.1016/j.bmcl.2015.10.019. Epub 2015 Oct 8.

Abstract

New phenazine derivatives with a methylamine linker, Pontemazines A (1) and B (2), were isolated from the culture broth of Streptomyces sp. UT1123. The structures of compounds 1 and 2 were determined by NMR spectroscopy and high-resolution mass spectrometry. These compounds consist of a 9-mehoxyphenazine connected to a benzamide functional group by a unique methylamine linker instead of the more common methyl ether. Pontemazines A and B possess a neuronal cell protective effect on glutamate-induced mouse hippocampal HT-22 cell damage.

Keywords: Methylamine linkage; Neuroprotection; Phenazine; Pontemazines; Streptomyces.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line
  • Glutamic Acid / toxicity
  • Magnetic Resonance Spectroscopy
  • Mice
  • Neuroprotective Agents / isolation & purification
  • Neuroprotective Agents / pharmacology*
  • Phenazines / isolation & purification
  • Phenazines / pharmacology*
  • Streptomyces / chemistry*

Substances

  • Neuroprotective Agents
  • Phenazines
  • pontemazine A
  • pontemazine B
  • Glutamic Acid