Reversible improvement in severe freezing of gait from Parkinson's disease with unilateral interleaved subthalamic brain stimulation

Parkinsonism Relat Disord. 2015 Dec;21(12):1469-70. doi: 10.1016/j.parkreldis.2015.09.047. Epub 2015 Oct 8.

Abstract

Freezing of gait causes considerable morbidity in patients with Parkinson's disease and is often refractory to conventional treatments. In this double-blind, randomized evaluation, unilateral interleaved deep brain stimulation in the subthalamic nucleus/substantia nigra pars reticulata region significantly improved freezing of gait in a patient with advanced Parkinson's disease.

Keywords: Freezing of gait; Interleaved deep brain stimulation; Parkinson's disease; Substantia nigra pars reticulata; Subthalamic nucleus.

Publication types

  • Case Reports
  • Letter
  • Research Support, N.I.H., Extramural
  • Video-Audio Media

MeSH terms

  • Deep Brain Stimulation / methods*
  • Double-Blind Method
  • Gait Disorders, Neurologic / etiology
  • Gait Disorders, Neurologic / therapy*
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Parkinson Disease / complications*
  • Substantia Nigra / physiopathology*
  • Subthalamic Nucleus / physiopathology*
  • Videotape Recording