Abstract
Several drugs have a QTc-prolonging effect and are metabolized by CYP3A4. The combination of QTc-prolonging drugs may act additive of the QTc interval. The risk increases additionally by co-administration of a CYP3A4-inhibiting substrate. This case report describes an incident with QTc prolongation which was probably caused by an interaction induced by a combination of amiodarone, clarithromycin and the CYP3A4-inhibitor fluconazole.
MeSH terms
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Aged
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Amiodarone / adverse effects*
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Amiodarone / therapeutic use
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Anti-Arrhythmia Agents / adverse effects*
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Anti-Arrhythmia Agents / therapeutic use
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Anti-Bacterial Agents / adverse effects*
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Anti-Bacterial Agents / therapeutic use
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Antifungal Agents / adverse effects*
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Antifungal Agents / therapeutic use
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Clarithromycin / adverse effects*
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Clarithromycin / therapeutic use
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Combined Modality Therapy / adverse effects
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Drug Interactions
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Electrocardiography
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Fluconazole / adverse effects*
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Fluconazole / therapeutic use
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Heart Rate / drug effects
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Humans
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Long QT Syndrome / chemically induced*
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Male
Substances
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Anti-Arrhythmia Agents
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Anti-Bacterial Agents
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Antifungal Agents
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Fluconazole
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Clarithromycin
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Amiodarone