Antibacterial activity of cyclo(L-Pro-L-Tyr) and cyclo(D-Pro-L-Tyr) from Streptomyces sp. strain 22-4 against phytopathogenic bacteria

Nat Prod Res. 2016 Sep;30(17):1980-3. doi: 10.1080/14786419.2015.1095747. Epub 2015 Oct 15.

Abstract

Two bioactive cyclic dipeptides, cyclo(L-Pro-L-Tyr) and cyclo(D-Pro-L-Tyr), were isolated from the culture broth of Streptomyces sp. strain 22-4 and tested against three economically important plant pathogens, Xanthomonas axonopodis pv. citri, Ralstonia solanacearum and Clavibacter michiganensis. Both cyclic dipeptides were active against X. axonopodis pv. citri and R. Solanacearum with MIC of 31.25 μg/mL. No activity could be observed against C. michiganensis.

Keywords: Cyclo(L-Pro-L-Tyr); Streptomyces; cyclo(D-Pro-L-Tyr); phytopathogenic bacteria.

MeSH terms

  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology*
  • Dipeptides / isolation & purification
  • Dipeptides / pharmacology*
  • Microbial Sensitivity Tests
  • Peptides, Cyclic / isolation & purification
  • Peptides, Cyclic / pharmacology*
  • Piperazines / isolation & purification
  • Piperazines / pharmacology
  • Plant Diseases / microbiology*
  • Ralstonia / drug effects
  • Streptomyces / chemistry*
  • Xanthomonas / drug effects

Substances

  • Anti-Bacterial Agents
  • Dipeptides
  • Peptides, Cyclic
  • Piperazines
  • tyrosyl-proline
  • maculosin