Dramatic transient improvement of metastatic BRAF(V600E)-mutated Langerhans cell sarcoma under treatment with dabrafenib

Samia Mourah; Gwenaël Lorillon; Véronique Meignin; Laetitia Vercellino; Constance de Margerie-Mellon; Cécile Pages; Lauriane Goldwirt; Alexandre How-Kit; Jorg Tost; Céleste Lebbe; Abdellatif Tazi

doi:10.1182/blood-2015-06-650036

Dramatic transient improvement of metastatic BRAF(V600E)-mutated Langerhans cell sarcoma under treatment with dabrafenib

Blood. 2015 Dec 10;126(24):2649-52. doi: 10.1182/blood-2015-06-650036. Epub 2015 Oct 14.

Authors

Affiliations

¹ Laboratoire de Pharmacologie Biologique, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France Université Paris Diderot, Sorbonne Paris Cité, Paris, France INSERM U976, Paris, France.
² Centre National de Référence de l'Histiocytose Langerhansienne, Service de Pneumologie, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France.
³ Service de Pathologie, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, INSERM UMR_S1165, Paris, France.
⁴ Service de Médecine Nucléaire, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France.
⁵ Service de Radiologie, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France.
⁶ Département de Dermatologie, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France.
⁷ Laboratoire de Pharmacologie Biologique, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France.
⁸ Laboratoire de Génomique Fonctionnelle, Fondation Jean Dausset-Centre d'Etude du Polymorphisme Humain, Paris, France.
⁹ Laboratoire d'Epigénétique, Centre National de Génotypage, Commissariat à l'énergie atomique et aux énergies alternatives-Institut de Génomique, Evry, France.
¹⁰ Département de Dermatologie, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France Université Paris Diderot, Sorbonne Paris Cité, Paris, France INSERM U976, Paris, France.
¹¹ Centre National de Référence de l'Histiocytose Langerhansienne, Service de Pneumologie, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France Université Paris Diderot, Sorbonne Paris Cité, Paris, France Equipe de Recherche en Biostatistiques et Epidémiologie Clinique, INSERM U1153 Centre de Recherche INSERM Epidémiologie et Statistique Paris Sorbonne Cité (CRESS), Paris, France.

PMID: 26468227
DOI: 10.1182/blood-2015-06-650036

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Antineoplastic Agents / therapeutic use*
Antineoplastic Combined Chemotherapy Protocols / administration & dosage
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Azetidines / administration & dosage
Cyclophosphamide / administration & dosage
Doxorubicin / administration & dosage
Drug Resistance, Neoplasm
Drug Substitution
Humans
Imidazoles / therapeutic use*
Indoles / administration & dosage
Langerhans Cell Sarcoma / diagnostic imaging
Langerhans Cell Sarcoma / drug therapy*
Langerhans Cell Sarcoma / genetics
Langerhans Cell Sarcoma / pathology
Lymph Nodes / diagnostic imaging
Lymph Nodes / pathology
MAP Kinase Kinase Kinases / antagonists & inhibitors
MAP Kinase Kinase Kinases / biosynthesis
MAP Kinase Kinase Kinases / genetics
Male
Middle Aged
Molecular Targeted Therapy*
Multimodal Imaging
Mutation, Missense
Neoplasm Proteins / antagonists & inhibitors*
Neoplasm Proteins / genetics
Oximes / therapeutic use*
Piperidines / administration & dosage
Point Mutation
Positron-Emission Tomography
Prednisone / administration & dosage
Protein Kinase Inhibitors / therapeutic use*
Proto-Oncogene Proteins / antagonists & inhibitors
Proto-Oncogene Proteins / biosynthesis
Proto-Oncogene Proteins / genetics
Proto-Oncogene Proteins B-raf / antagonists & inhibitors*
Proto-Oncogene Proteins B-raf / genetics
Recurrence
Sulfonamides / administration & dosage
Tomography, X-Ray Computed
Vemurafenib
Vincristine / administration & dosage

Substances

Antineoplastic Agents
Azetidines
Imidazoles
Indoles
Neoplasm Proteins
Oximes
Piperidines
Protein Kinase Inhibitors
Proto-Oncogene Proteins
Sulfonamides
Vemurafenib
Vincristine
Doxorubicin
Cyclophosphamide
BRAF protein, human
Proto-Oncogene Proteins B-raf
MAP Kinase Kinase Kinases
MAP3K8 protein, human
cobimetinib
dabrafenib
Prednisone

Supplementary concepts

CHOP protocol