Latent tuberculous infection in schoolchildren and contact tracing in Matlosana, North West Province, South Africa

L Lebina; P M Abraham; M Milovanovic; K Motlhaoleng; R E Chaisson; M Rakgokong; J Golub; E Variava; N A Martinson

doi:10.5588/ijtld.15.0370

Latent tuberculous infection in schoolchildren and contact tracing in Matlosana, North West Province, South Africa

Int J Tuberc Lung Dis. 2015 Nov;19(11):1290-2. doi: 10.5588/ijtld.15.0370.

Authors

L Lebina¹, P M Abraham¹, M Milovanovic¹, K Motlhaoleng¹, R E Chaisson², M Rakgokong¹, J Golub², E Variava³, N A Martinson⁴

Affiliations

¹ Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa.
² Johns Hopkins University Center for TB Research, Baltimore, Maryland, USA.
³ Department of Medicine, Klerksdorp-Tshepong Hospital Complex, North West Department of Health, Johannesburg, South Africa.
⁴ Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa; Johns Hopkins University Center for TB Research, Baltimore, Maryland, USA; Department of Science and Technology/National Research Foundation Centre of Excellence for Biomedical TB Research, University of the Witwatersrand, Johannesburg, South Africa; Soweto Matlosana Collaborative Centre for HIV/AIDS & TB, Medical Research Council, Tygerberg, Cape Town, South Africa.

Abstract

This is a cross-sectional study to estimate the prevalence of latent tuberculous infection (LTBI) and the annual risk of tuberculous infection (ARTI) among a sample of children aged 5 and 7 years in Matlosana, South Africa. LTBI prevalence was significantly higher in children aged 7 years (n = 704) (19.7%, 95%CI 16.75-22.65) than in those aged 5 years (212/1401, 15.1%, 95%CI 13.23-16.97) (P = 0.0075). The ARI was 2.9% (95%CI 2.2-3.6).

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Child
Child, Preschool
Contact Tracing / methods*
Cross-Sectional Studies
Female
Humans
Latent Tuberculosis / epidemiology*
Male
Schools
South Africa / epidemiology
Tuberculin Test

Grants and funding

P30 AI094189/AI/NIAID NIH HHS/United States