Bioactive phloroglucinols from Mallotus oppositifolius

Fitoterapia. 2015 Dec:107:100-104. doi: 10.1016/j.fitote.2015.09.015. Epub 2015 Oct 14.

Abstract

The two new acylphloroglucinol derivatives, methylene-bis-aspidinol AB (1) and mallopposinol (2), together with the nine known compounds, aspidinol B (3), methylene-bis-aspidinol (4), (+)-α-tocopherol (5), lupeol (6), stigmasterol (7), phytol (8), bergenin (9), squalene (11) and methyl gallate (10) were isolated from the leaves of Mallotus oppositifolius. Their structures were elucidated by spectral analysis including MS, 1D and 2D-NMR spectroscopy. In vitro trypanocidal and antileishmanial activities of compounds 1-9 were evaluated. Mallopposinol (2) and aspidinol B (3) displayed weak antileishmanial activities against Leishmania donovani promastigotes, with EC50 values of 21.3 and 38.8μM, respectively. Only the methylene-bis-aspidinol (4) exhibited trypanocidal activity against Trypanosoma brucei brucei trypomastigotes (LC100=0.8μM) similar to the reference drug pentamidine (LC100=0.4μM).

Keywords: (+)-tocophérol (PubChem CID: 14985); Aspidinol B (PubChem CID: 122841); Euphorbiaceae; Leishmania donovani; Mallotus oppositifolius; Methylene-bis-aspidinol (PubChem CID: 617027); Phloroglucinol; Trypanosoma brucei brucei; bergenin (PubChem CID: 66065); lupeol (PubChem CID: 259846); methyl gallate (PubChem CID: 7428); phytol (PubChem CID: 5280435); squalene (PubChem CID: 638072); stigmasterol (PubChem CID: 5280794).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiprotozoal Agents / isolation & purification
  • Antiprotozoal Agents / pharmacology*
  • Inhibitory Concentration 50
  • Leishmania donovani / drug effects*
  • Mallotus Plant / chemistry*
  • Molecular Structure
  • Phloroglucinol / isolation & purification
  • Phloroglucinol / pharmacology*
  • Plant Extracts / chemistry
  • Plant Leaves / chemistry
  • Trypanosoma brucei brucei / drug effects*

Substances

  • Antiprotozoal Agents
  • Plant Extracts
  • Phloroglucinol