Mesoporous Pt Nanotubes as a Novel Sensing Platform for Sensitive Detection of Intracellular Hydrogen Peroxide

ACS Appl Mater Interfaces. 2015 Nov 4;7(43):24288-95. doi: 10.1021/acsami.5b08146. Epub 2015 Oct 22.

Abstract

Controlling the shape, structure, and surface morphology of nanomaterials is of great significance in optimizing sensitivity and catalytic performances in biosensing applications. The main goal of employing Pt-based nanomaterials is to increase their utilization efficiency due to their high cost. Herein, we report the synthesis of mesoporous Pt nanotubes using Pluronic P123 as soft templates and Ag nanowires with 50 nm in diameter as hard templates. The resultant materials with unique structures show high sensitivity and stability toward H2O2 detection with low cellular cytotoxicity. The high sensitivity and catalytic properties are attributed to the mesopores and hollow structures making the inner Pt surfaces accessible to reaction media and enlarging the total surface area and one-dimensional structure facilitating the mass diffusion rate.

Keywords: H2O2 detection; colorimetric method; hollow nanotubes; living cell; mesoporous.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Biosensing Techniques / methods*
  • Catalysis
  • Diffusion
  • Electrochemical Techniques / methods
  • Humans
  • Hydrogen Peroxide / chemistry*
  • MCF-7 Cells
  • Metal Nanoparticles / chemistry*
  • Microscopy, Electron, Transmission
  • Nanotubes / chemistry*
  • Nanowires / chemistry
  • Platinum / chemistry*
  • Poloxalene / chemistry
  • Silver / chemistry
  • Temperature
  • X-Ray Diffraction

Substances

  • pluronic block copolymer P123
  • Silver
  • Platinum
  • Poloxalene
  • Hydrogen Peroxide