Abstract
In this study, six new compounds containing morpholine and 5(4H)-oxazolone rings were synthesized. Structures of the new compounds using IR, (1)H NMR, mass spectroscopy and elemental analysis were characterized. All new compounds (4a-4f) have a strong inhibitory effect against mushroom tyrosinase. And the inhibitory effects of these compounds were compared with Kojic acid as standard.
Keywords:
5(4H)-Oxazolone; Morpholine; Synthesis; Tyrosinase inhibitor.
Copyright © 2015 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Agaricales / enzymology
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Animals
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Cell Line, Tumor
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Cell Survival / drug effects
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / metabolism
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Enzyme Inhibitors / pharmacology
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Inhibitory Concentration 50
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Melanins / metabolism
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Monophenol Monooxygenase / antagonists & inhibitors*
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Monophenol Monooxygenase / metabolism
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Morpholines / chemistry*
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Oxazolone / chemistry*
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Oxazolone / metabolism
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Oxazolone / pharmacology
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Protein Binding
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Pyrones / chemistry
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Pyrones / metabolism
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Up-Regulation / drug effects
Substances
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Enzyme Inhibitors
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Melanins
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Morpholines
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Pyrones
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Oxazolone
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kojic acid
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morpholine
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Monophenol Monooxygenase