Of Brains and Blood: Developmental Origins of Glioma Diversity?

Mariella G Filbin; Charles D Stiles

doi:10.1016/j.ccell.2015.09.013

Of Brains and Blood: Developmental Origins of Glioma Diversity?

Cancer Cell. 2015 Oct 12;28(4):403-404. doi: 10.1016/j.ccell.2015.09.013.

Authors

Mariella G Filbin¹, Charles D Stiles²

Affiliations

¹ Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
² Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address: charles_stiles@dfci.harvard.edu.

PMID: 26461085
DOI: 10.1016/j.ccell.2015.09.013

Abstract

The multiple cell types of brain and blood arise from pluripotent stem cells via progressively more committed downstream progenitors. In this issue of Cancer Cell, Alcantara Llaguno and colleagues show that identical genetic drivers give rise to distinct glioma subtypes within differentially committed neural progenitors-a paradigm well established for leukemias.

Publication types

Comment

MeSH terms

Adult Stem Cells / pathology*
Animals
Brain Neoplasms / genetics*
Brain Neoplasms / pathology*
Central Nervous System / cytology*
Glioblastoma / genetics*
Glioblastoma / pathology*
Humans