Shifting the Evolving CAR T Cell Platform into Higher Gear

Cancer Cell. 2015 Oct 12;28(4):401-402. doi: 10.1016/j.ccell.2015.09.014.

Abstract

In this issue of Cancer Cell, Zhao and colleagues test various chimeric antigen receptor (CAR) T cells to show that CD28-CD3ζ CAR T cells that constitutively express 4-1BBL promote T cell expansion and tumor eradication while reducing exhaustion. The results have important implications for the development of effective CAR T cell therapies in cancer patients.

Publication types

  • Comment

MeSH terms

  • CD28 Antigens / immunology*
  • Hematologic Neoplasms / immunology*
  • Humans
  • Receptors, Antigen / immunology*
  • T-Lymphocytes / immunology*
  • Tumor Necrosis Factor Receptor Superfamily, Member 9 / immunology*

Substances

  • CD28 Antigens
  • Receptors, Antigen
  • Tumor Necrosis Factor Receptor Superfamily, Member 9