Viruses that ride on the coat-tails of actin nucleation

Timothy P Newsome; N Bishara Marzook

doi:10.1016/j.semcdb.2015.10.008

Viruses that ride on the coat-tails of actin nucleation

Semin Cell Dev Biol. 2015 Oct:46:155-63. doi: 10.1016/j.semcdb.2015.10.008. Epub 2015 Oct 13.

Authors

Timothy P Newsome¹, N Bishara Marzook²

Affiliations

¹ School of Molecular Bioscience, The University of Sydney, Sydney, NSW, 2006, Australia. Electronic address: tim.newsome@sydney.edu.au.
² School of Molecular Bioscience, The University of Sydney, Sydney, NSW, 2006, Australia.

PMID: 26459972
DOI: 10.1016/j.semcdb.2015.10.008

Abstract

Actin nucleation drives a diversity of critical cellular processes and the motility of a select group of viral pathogens. Vaccinia virus and baculovirus, Autographa californica multiple nucleopolyhedrovirus, recruit and activate the cellular actin nucleator, the Arp2/3 complex, at the surface of virus particles thereby instigating highly localized actin nucleation. The extension of these filaments provides a mechanical force that bestows the ability to navigate the intracellular environment and promote their infectious cycles. This review outlines the viral and cellular proteins that initiate and regulate the signalling networks leading to viral modification of the actin cytoskeleton and summarizes recent insights into the role of actin-based virus transport.

Keywords: Actin; Arp2/3 complex; Baculovirus; Cytoskeleton; Microtubules; N-WASP; Vaccinia; Virus transport.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Actin-Related Protein 2-3 Complex / metabolism*
Actins / metabolism*
Animals
Biological Transport
Host-Pathogen Interactions
Humans
Models, Biological
Nucleopolyhedroviruses / metabolism*
Nucleopolyhedroviruses / physiology
Vaccinia virus / metabolism*
Vaccinia virus / physiology
Virus Diseases / metabolism*
Virus Diseases / virology

Substances

Actin-Related Protein 2-3 Complex
Actins