Abstract
Colistin-resistant mutants were obtained from 17 colistin-susceptible strains of Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli. The stability of colistin resistance in these mutants was investigated. Three of four colistin-resistant P. aeruginosa mutants recovered colistin susceptibility in colistin-free medium; however, colistin-susceptible revertants were obtained from only one strain each of A. baumannii and E. coli. No susceptible revertants were obtained from K. pneumoniae mutants.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acinetobacter baumannii / drug effects*
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Acinetobacter baumannii / genetics
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Acinetobacter baumannii / metabolism
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Anti-Bacterial Agents / pharmacology*
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism
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Colistin / pharmacology*
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Drug Resistance, Bacterial / drug effects*
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Drug Resistance, Bacterial / genetics
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Escherichia coli / drug effects*
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Escherichia coli / genetics
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Escherichia coli / metabolism
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Gene Expression
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Klebsiella pneumoniae / drug effects*
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Klebsiella pneumoniae / genetics
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Klebsiella pneumoniae / metabolism
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Membrane Proteins / genetics
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Membrane Proteins / metabolism
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Microbial Sensitivity Tests
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Mutation Rate
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Pseudomonas aeruginosa / drug effects*
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Pseudomonas aeruginosa / genetics
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Pseudomonas aeruginosa / metabolism
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Transcription Factors / genetics
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Transcription Factors / metabolism
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Membrane Proteins
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PhoQ protein, Bacteria
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PmrB protein, bacteria
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Transcription Factors
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pmrA protein, Bacteria
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PhoP protein, Bacteria
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Colistin