Functional promoter polymorphisms of the receptor for advanced glycation end products in children and adolescents with type 1 diabetes

Mol Cell Probes. 2015 Dec;29(6):503-506. doi: 10.1016/j.mcp.2015.10.001. Epub 2015 Oct 9.

Abstract

RAGE promoter polymorphisms are associated with increases in RAGE expression. A case-control association study was conducted involving a Euro-Brazilian population of children and adolescents with type 1 diabetes (n = 90) and healthy controls (n = 105), which were matched by sex and age. Genotyping by PCR-RFLP the -429T>C (rs1800625), -374T>A (rs1800624), and 63 bp deletion/insertion (-407 to -345 bp) showed no significant differences (P > 0.05) between the groups.

Keywords: Genetic variability; RAGE gene; Single nucleotide polymorphism; Type 1 diabetes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Brazil
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Diabetes Mellitus, Type 1 / genetics*
  • Europe
  • Female
  • Genetic Association Studies / methods
  • Genotype
  • Genotyping Techniques / methods
  • Humans
  • Infant
  • Male
  • Polymorphism, Restriction Fragment Length*
  • Promoter Regions, Genetic*
  • Receptor for Advanced Glycation End Products / genetics*

Substances

  • Receptor for Advanced Glycation End Products