A case of concomitant chronic lymphocytic leukaemia and hairy cell leukaemia evaluated for IGHV-D-J rearrangements and BRAF-V600E mutation: lack of evidence for a common origin

Br J Haematol. 2016 Jul;174(2):329-31. doi: 10.1111/bjh.13770. Epub 2015 Oct 12.

Authors

Marzia Cavalli¹, Caterina Ilari¹, Ilaria Del Giudice², Marilisa Marinelli¹, Irene Della Starza¹, Maria Stefania De Propris¹, Lucia Anna De Novi¹, Vittorio Nunes¹, Luciana Cafforio¹, Sara Raponi¹, Francesca Mancini¹, Francesca Romana Mauro¹, Enrico Tiacci³, Brunangelo Falini³, Anna Guarini¹, Robin Foà¹

Affiliations

¹ Department of Cellular Biotechnologies and Haematology, "Sapienza" University of Rome, Rome, Italy.
² Department of Cellular Biotechnologies and Haematology, "Sapienza" University of Rome, Rome, Italy. delgiudice@bce.uniroma1.it.
³ Institute of Haematology and Centre for Haemato-Oncology Research (C.R.E.O.), University and Hospital of Perugia, Perugia, Italy.

PMID: 26455504
DOI: 10.1111/bjh.13770

No abstract available

Keywords: BRAF V600E; IGH; chronic lymphocytic leukaemia; hairy cell leukaemia; quantitative PCR.

Publication types

Case Reports
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Clone Cells / pathology
Gene Rearrangement
Genes, Immunoglobulin Heavy Chain / genetics*
Humans
Leukemia, Hairy Cell / complications
Leukemia, Hairy Cell / genetics*
Leukemia, Hairy Cell / pathology
Leukemia, Lymphocytic, Chronic, B-Cell / complications
Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
Leukemia, Lymphocytic, Chronic, B-Cell / pathology
Male
Middle Aged
Mutation
Proto-Oncogene Proteins B-raf / genetics*

Substances

Proto-Oncogene Proteins B-raf