Abstract
A rational design of squaraine dyes with lipophilic and zwitterionic groups tunes cell entry, allowing for selective far-red/near-infrared imaging of plasma membrane vs. endoplasmic reticulum. They exhibit up to 110-fold fluorescence enhancement in biomembranes and enable cellular imaging at 1 nM concentration, which make them the brightest membrane probes to date.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Membrane / chemistry*
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Cyclobutanes / chemical synthesis
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Cyclobutanes / chemistry*
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Endoplasmic Reticulum / chemistry*
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Fluorescence
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Fluorescent Dyes / chemical synthesis
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Fluorescent Dyes / chemistry*
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HeLa Cells
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Humans
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Molecular Structure
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Phenols / chemical synthesis
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Phenols / chemistry*
Substances
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Cyclobutanes
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Fluorescent Dyes
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Phenols
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squaraine