Anti-Mycobacterium tuberculosis activity of antituberculosis drugs and amoxicillin/clavulanate combination

J Microbiol Immunol Infect. 2016 Dec;49(6):980-983. doi: 10.1016/j.jmii.2015.08.025. Epub 2015 Sep 21.

Abstract

We report the in vitro drugs interaction by the resazurin drugs combination microtiter assay (REDCA) of amoxicillin (AMO)/clavulanate (CLAV) with isoniazid (INH), ethambutol (EMB), and rifampicin (RIF) against susceptible and resistant Mycobacterium tuberculosis isolates. The addition of AMO/CLAV to classical antituberculosis drugs should be explored as a promising alternative for the treatment of resistant tuberculosis (TB).

Keywords: Mycobacterium tuberculosis; amoxicillin/clavulanate; checkerboard; synergism; tuberculosis.

MeSH terms

  • Amoxicillin / pharmacology*
  • Antitubercular Agents / pharmacology*
  • Clavulanic Acid / pharmacology*
  • Drug Resistance, Multiple, Bacterial
  • Ethambutol / pharmacology*
  • Humans
  • Isoniazid / pharmacology*
  • Microbial Sensitivity Tests
  • Mycobacterium tuberculosis / drug effects*
  • Mycobacterium tuberculosis / isolation & purification
  • Oxazines / analysis
  • Rifampin / pharmacology*
  • Xanthenes / analysis

Substances

  • Antitubercular Agents
  • Oxazines
  • Xanthenes
  • resazurin
  • Clavulanic Acid
  • Amoxicillin
  • Ethambutol
  • Isoniazid
  • Rifampin